Drug Targets for Brain Aging: Discovering Targets by Analyzing Proteomic Changes in Longitudinal Human Datasets
- Using composite health outcome endpoints combining cognition, mobility, and molecular readouts to capture the full spectrum of aging biology
- Leveraging circulating proteomics and future incidence of neurodegeneration to identify novel therapeutic targets that address root causes rather than downstream pathology
- From platform to pipeline: Case study of translation from target discovery to clinical program