Joseph Rayman
Principal Investigator Columbia University
Seminars
Wednesday 28th January 2026
A Novel Strategy for Inhibiting Tau Oligomerization in Aging & Disease
4:45 pm
- Protein quality control systems decline with age, increasing the likelihood that aberrant protein conformations will accumulate and promote cellular dysfunction
- With loss of proteostasis, endogenous mechanisms can opportunistically give rise to tau oligomers, which may be the most pathogenic species of tau protein
- In aged wild-type mice and tau transgenic models, pharmacological inhibition of cellular pathways that generate tau oligomers is accompanied by broad phenotypic amelioration
- Reduction of tau oligomer levels in the CNS is a promising therapeutic strategy for tauopathies, but may be generally relevant to diseases of aging
